Naproxen sodium has a longer half-life compared to other NSAID options, but headache relief rates at 2 hours after initial treatment are lower than ibuprofen. [6] [7] Naproxen sodium dosing recommendations: 550 mg every 12 hours; can increase the dosage to 825mg PO if needed; do not exceed the max of 1375 mg daily. Aleve has an average rating of 7.0 out of 10 from a total of 154 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 24% reported a negative effect. Diclofenac has an average rating of 7.4 out of 10 from a total of 686 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 20% reported a negative effect. Ibuprofen up to 1200 mg per day or naproxen up to 1000 mg daily are first-line options, consider the need for monitoring. COX-2 inhibitors, aceclofenac, diclofenac, and high-dose ibuprofen are contraindicated. For people with severe renal impairment (estimated glomerular filtration rate [eGFR] less than 30 mL/minute/1.73 m 2): Both Meloxicam and Diclofenac are medications that treat pain and inflammation-related issues. However, Meloxicam also treats rheumatoid arthritis. As detected in the study above, Meloxicam was considerably more tolerable as compared to Diclofenac. But the results also noticed both showed equally significant outcomes in treating the pain. Bottom Line: Short-term meloxicam at the 7.5-mg daily dosage is less likely than piroxicam, diclofenac, or naproxen to be associated with serious GI complications. However, the absolute risk Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed more. Prescription only. Prednisone effectively controls inflammation and an overactive immune system but may not be suitable for everybody. Here are the leraning points which suggest that taking anti-inflammatory medications was harmful than under going replacement surgery. Cause of patient death was highest for naproxen and lowest for total hip replacement. Highest gastrointestinal complications were reported for diclofenac and lowest for total knee replacement. Meloxicam and Celebrex are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat arthritis. Meloxicam is a generic version of Mobic while Celebrex is the brand name for celecoxib. Both drugs work by preventing the release of inflammatory substances called prostaglandins. By blocking their release in the body, meloxicam and Celebrex can Diclofenac extended-release tablets are usually taken once a day, and in rare cases are taken twice a day, if needed to control pain. Diclofenac tablets and diclofenac delayed-release tablets are usually taken 2, 3, or 4 times a day. Diclofenac solution is taken without food as a one dose treatment to relieve the pain of migraine headaches. The most frequently-occurring adverse events in both groups were of a gastrointestinal (GI) nature. However, there was a higher incidence (26 vs 16%) of GI adverse events in the diclofenac group compared with the meloxicam group. Both drugs were well tolerated when assessed by the patients on a visual analog scale (VAS). Zjle.